The first key insight is that the clues can be grouped into pairs; in each pair, the two answers have the same ending string, but beginning strings that are opposites:

Secure (2 wds.) = HOLD FAST; Morning meal = BREAKFAST
Name from a TV estate = DOWNTON; Pulitzer winner Sinclair = UPTON
Railroad track supports = CROSSTIES; Subtle distinctions = NICETIES
Endeavor = UNDERTAKE; Catch up to = OVERTAKE
A large volume = TOME; Wharton protagonist = FROME
Jurassic Park's Sam = NEILL; Hogwash = SWILL
How mom and dad behave = PARENTALLY; In every respect = TOTALLY
Bamboozle = CONFOUND; Philosophically deep = PROFOUND
Zurich, Geneva, or Zug = CANTON; E.g., The Sign of Four... = CANON

A line connecting the two dots for a given pair crosses through various letters, and one blank disk. The various letters (plus some other letter represented by the blank disk) are an anagram of an antonym of the common ending string for the pair. For example, the HOLD FAST / BREAKFAST line crosses through a K, a P, a blank, and a Y. An antonym of FAST is POKY, so the blank disk must stand for an O. The antonyms and extra letters (in the same order as the pairs above) are: P(O)KY, MODI(C)UM, B(E)ATS, (D)ONATE, YO(U), (R)OBUST, E(N)EMY, LOS(T), and (I)DLE.

After doing all this, there are many disks with no lines through them. Reading roughly top-to-bottom, left-to-right, these spell: SYNONYM READ ACROSS OR ANTONYM IF READ DOWN FIVE LETTERS. Reading the disks to which we added the extra letters in left-to-right order gives INTRODUCE; reading them in top-to-bottom order gives REDUCTION. The word that is a synonym of INTRODUCE, an antonym of REDUCTION, and five letters long is RAISE.

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